Gradogna
A, Fenollar-Ferrer C, Forrest LR, Pusch M.
2012. Dissecting a regulatory calcium-binding site of CLC-K kidney
chloride channels. J Gen
Physiol 140:681-696
Costa
A, Gutla PV, Boccaccio A, Scholz-Starke J, Festa M, Basso B, Zanardi I,
Pusch M, Schiavo FL, Gambale F, Carpaneto A.
2012. The Arabidopsis central vacuole as an expression system for
intracellular transporters: functional characterization of the Cl-/H+
exchanger CLC-7. J
Physiol 590:3421-3430
Zifarelli
G, De Stefano S, Zanardi I, Pusch
M. 2012. On the mechanism of gating charge movement of ClC-5,
a
human Cl−/H+ antiporter. Biophys J 102:2060-2069
Jeworutzki E, López-Hernández T, Capdevila-Nortes X, Sirisi S, Bengtsson L, Montolio M, Zifarelli G, Arnedo T, Müller CS, Schulte U, Nunes V, Martínez A, Jentsch TJ, Gasull X, Pusch M, Estévez R. 2012. GlialCAM, a Protein Defective in a Leukodystrophy, Serves as a ClC-2 Cl(-) Channel Auxiliary Subunit. Neuron 73:951-961
Ruivo R, Bellenchi GC, Chen X, Zifarelli G, Sagné C, Debacker C, Pusch M, Supplisson S, Gasnier B. 2012. Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin. Proc Natl Acad Sci U S A. 109(5):E210-E217
De
Stefano S, Pusch
M, Zifarelli G. 2011. Extracellular determinants of anion
discrimination of the Cl-/H+ antiporter protein CLC-5. J Biol Chem
286:44134-44144
Strutz-Seebohm
N,
Pusch M, Wolf S, Stoll R, Tapken D, Gerwert K, Attali B, Seebohm G.
2011. Structural basis of slow activation gating in the cardiac I Ks
channel complex. Cell
Physiol Biochem
Gradogna
A, Babini
E, Picollo A, Pusch M. 2010. A regulatory calcium-binding
site at
the subunit interface of CLC-K kidney chloride channels. J Gen Physiol
136:311-323 Zifarelli
G,
Liantonio A, Gradogna A, Picollo A, Gramegna G, De Bellis M, Murgia AR,
Babini E, Camerino DC, Pusch M. 2010. Identification of sites
responsible for the potentiating effect of niflumic acid on ClC-Ka
kidney chloride channels.
Brit J
Pharmacol. 160: 1652-1661 Pangrazio
A, Pusch
M, Caldana E, Frattini A, Lanino E, Tamhankar PM, Phadke S, Lopez AG,
Orchard P, Mihci E, Abinun M, Wright M, Vettenranta K, Bariae I, Melis
D, Tezcan I, Baumann C, Locatelli F, Zecca M, Horwitz E, Mansour LS,
Van Roij M, Vezzoni P, Villa A, Sobacchi C. 2010. Molecular
and
clinical heterogeneity in CLCN7-dependent osteopetrosis: report of 20
novel mutations. Human
Mutat.
31:E1071-E1080 Zifarelli
G, Pusch M. 2009. Conversion of the 2 Cl(-)/1 H(+) antiporter
ClC-5
in a
NO(3)(-)/H(+) antiporter by a single point mutation. EMBO J. 28:175-182 Zdebik
AA,
Zifarelli G, Bergsdorf E-Y, Soliani P, Scheel O, Jentsch TJ, Pusch M.
2008.
Determinants of anion-proton coupling in mammalian endosomal CLC
proteins. J
Biol Chem
283:4219-4227 Zifarelli
G, Soliani P, Pusch M.
2008. Buffered
diffusion around a spherical proton pumping cell: a theoretical
analysis. Biophys
J 94: 53-62 Zifarelli
G, Murgia AR, Soliani P, Pusch M. 2008. Intracellular proton
regulation of ClC-0. J
Gen Physiol.
132:185-198 Kahlig
KM, Rhodes TH, Pusch M, Freilinger T, Pereira-Monteiro JM, Ferrari MD,
van den Maagdenberg AM, Dichgans M, George AL Jr. 2008.
Divergent
sodium channel defects in familial hemiplegic migraine. Proc
Natl Acad Sci U S A.
105:9799-9804 Zifarelli
G, Pusch M. 2008. The muscle chloride
channel ClC-1 is not directly regulated by intracellular ATP. J Gen Physiol
131:109-116 de
Vries B,
Freilinger T, Vanmolkot KRJ, Koenderink JB, Stam AH, Terwindt GM,
Babini E, van
den Boogerd EH, van den Heuvel JJMW, Frants RR, Haan J, Pusch M, van
den
Maagdenberg AMJM, Ferrari MD, Dichgans M. 2007. Systematic analysis of three
FHM genes in 39 sporadic patients with hemiplegic migraine. Neurology
69:2170-2176. Liantonio
A, Giannuzzi V, Picollo A, Babini E, Pusch M, Conte
Camerino D. 2007. Niflumic acid inhibits chloride conductance of rat skeletal muscle by directly inhibiting the CLC-1 channel and by increasing intracellular calcium. Br
J Pharmacol. 150:235-47. Liantonio
A, Picollo A, Babini E, Carbonara G, Fracchiolla G, Loiodice F,
Tortorella V, Pusch M, Camerino DC. 2006. Activation and
inhibition
of kidney CLC-K chloride channels by fenamates. Mol Pharmacol 69:
165-173. Chen
X, Paukert M, Kadurin I, Pusch M, Gründer S. 2006.
Strong
modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in
competition with extracellular calcium. Neuropharmacology,
50, 964-974. Pusch
M, Jentsch TJ. 2005. Unique structure and function of
chloride
transporting
CLC proteins. IEEE Trans Nanobioscience 4:49-57. pdf.
Picollo
A, Pusch M. 2005. Chloride / proton antiporter
activity of
mammalian
CLC proteins ClC-4 and ClC-5. Nature, 436, 420-423.
Schenzer
A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grötzinger J,
Schwake
M. 2005. Molecular determinants of KCNQ K+
channel
sensitivity to
the
anticonvulsant retigabine. J Neurosc 25,
5051-5060.
Dichgans
M, Freilinger T, Eckstein G, Babini E,
Lorenz-Depiereux B,
Biskup S, Ferrari MD, Herzog J, van den Maagdenberg AMJM,
Pusch
M,
Strom TM. 2005. Mutation in the neuronal voltage-gated sodium
channel
SCN1A causes familial hemiplegic migraine. Lancet,
366,
371-377.
Teijido
O, Martinez A, Pusch M, Zorzano A, Soriano E, Del Rio JA, Palacin M,
Estévez
R. 2004. Localization and functional analyses of the MLC1
protein
involved
in megalencephalic leukoencephalopathy with subcortical
cysts. Hum
Mol Genet 13, 2581-2594.
Paukert
M, Babini E, Pusch M, Gründer, S. 2004.
Identification of the
Ca2+ Blocking Site of Acid-sensing Ion Channel
(ASIC) 1:
Implications
for
Channel Gating. J Gen Physiol 124, 383-394. Pusch M. 2004. Ca(2+)-activated
chloride channels go molecular. J Gen
Physiol 123:323-325. Conte
Camerino D, Tricarico D, Pierno S, Desaphy JF, Liantonio A, Pusch M,
Burdi
R, Camerino C, Fraysse B, De Luca A. 2004. Taurine and
skeletal
muscle
disorders. Neurochem Res 29:135-142.
Picollo
A, Liantonio A, Didonna MP, Elia L, Camerino DC, Pusch M.
2004.
Molecular
determinants of differential pore blocking of kidney CLC-K chloride
channels.
EMBO Rep 5:584-589.
Liantonio
A, Pusch M, Picollo A, Guida P, De Luca A, Pierno S, Fracchiolla G,
Loiodice
F, Tortorella P, Conte Camerino D. 2004. Investigations of
pharmacological
properties of the renal CLC-K1 chloride channel co-expressed with
barttin
by the use of 2-(p-chlorophenoxy) propionic acid derivatives and other
structurally unrelated chloride channels blockers. J Am Soc
Nephrol
15:13-20.
Seebohm
G, Pusch M, Chen J, Sanguinetti MC. 2003. Pharmacological
activation
of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ
Res 23, 941-7.
Traverso
S, Elia L, Pusch M. 2003. Gating competence of constitutively
open
CLC-0 mutants revealed by the interaction with a small organic
Inhibitor.
J
Gen Physiol 122, 295-306.
Accardi
A, Pusch M. 2003. Conformational changes in the pore of
CLC-0.
J
Gen Physiol 122, 277-293.
Liantonio
A, De Luca A, Pierno S, Didonna MP, Loiodice F, Fracchiolla G,
Tortorella P, Antonio L, Bonerba E, Traverso S, Elia L, Picollo A,
Pusch M, Camerino DC. 2003. Structural requisites of
2-(p-chlorophenoxy)propionic acid analogues for activity on native rat
skeletal muscle chloride conductance and on heterologously expressed
CLC-1. Br J Pharmacol 139:1255-1264.
Seebohm
G, Sanguinetti MC, Pusch M. 2003. Tight coupling of Rubidium
conductance
and inactivation in human KCNQ1 potassium channels. J
Physiol
(Lond) 552, 369-78.
Moran
O, Traverso S, Elia L, Pusch M. 2003. Molecular modeling of
p-chlorophenoxyacetic
acid binding to the CLC-0 channel. Biochemistry 42,
5176-5185.
Estévez
R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M. 2003.
Conservation
of chloride channel structure revealed by an inhibitor binding site in
ClC-1. Neuron 38, 47-59.
Pusch M,
Accardi A, Liantonio A, Guida P, Traverso S, Camerino DC, Conti F.
2002. Mechanisms of block of muscle type
CLC chloride channels (Review). Mol Membr
Biol 19:285-92. Seebohm
G, Lerche C, Pusch M, Steinmeyer K, Bruggemann A, Busch AE.
2001. A
kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by
the
chromanol 293B. Br J Pharmacol 134:1647-1654.
Accardi
A, Ferrera L, Pusch M. 2001. Drastic reduction of
the slow
gate
of human ClC-1 by mutation C277S. J Physiol (Lond)
534:745-752.
Pusch
M, Accardi A, Liantonio A, Ferrera L, De Luca A, Camerino DC, Conti F.
2001. Mechanism of block of single protopores of the Torpedo chloride
channel
CLC-0 by 2-(p-chlorophenoxy)butyric acid (CPB). J Gen Physiol
118:45-62.
Pusch
M, Ferrera L, Friedrich T. 2001. Two open states and
rate-limiting
gating steps revealed by intracellular Na+ block
of human
KCNQ1 and
KCNQ1/KCNE1
K+ channels. J Physiol (Lond)
533:135-43.
Rychkov
G, Pusch M, Roberts M, Bretag A. 2001. Interaction of
hydrophobic
anions
with the rat skeletal muscle chloride channel ClC-1: effects on
permeation
and gating. J Physiol (Lond) 530:379-93. Pusch M. 2001. Chloride
channelopathies. Pharmaceutical News
8:45-51. Pusch M. 2000. Negative thinking: anion
channels. Review of "Chloride channels", edited by R. Kozlowski (Iris
Media Limited, Feb. 2000), Nature Cell
Biol 2:E150. Accardi
A, Pusch M. 2000. Fast and slow gating relaxations in the
muscle
chloride
channel CLC-1. J Gen Physiol 116:433-444.
Pusch
M, Liantonio A, Bertorello L, Accardi A, De Luca A, Pierno S,
Tortorella
V, Conte Camerino D. 2000. Pharmacological characterization
of
chloride
channels belonging to the ClC family by the use of chiral clofibric
acid
derivatives. Mol Pharmacol 58:498-507.
Nobile
M, Pusch M, Rapisarda C, Ferroni S. 2000. Single-channel
analysis
of
a ClC-2-like chloride conductance in cultured rat cortical astrocytes.
FEBS
Lett 479:10-14.
Schwake
M, Pusch M, Kharkovets T, Jentsch TJ. 2000. Surface
expression and
single channel properties of KCNQ2/KCNQ3, M-type K+
channels
involved
in
epilepsy. J Biol Chem 275:13343-13348. Pusch
M, Bertorello L, Conti F. 2000. Gating and flickery block
differentially
affected by rubidium in homomeric KCNQ1 and heteromeric KCNQ1/KCNE1
potassium
channels. Biophys J 78:211-226. Schriever
AM, Friedrich T, Pusch M, Jentsch
TJ. 1999. CLC chloride channels in Caenorhabditis
elegans. J Biol Chem
274:34238-34244. Pusch M. 1998. Increase of the
single-channel conductance of KvLQT1 potassium channels induced by the
association with minK. Pflügers
Arch Eur J Physiol 437:172-174.
Jentsch
TJ, Pusch M, Schwappach B, Steinmeyer K.
1997. Myotonia
and other diseases due to chloride
channels mutations. Nova Acta Lorenz
C, Pusch M, Jentsch TJ. 1996.
Heteromeric ClC channels with novel properties. Proc Natl
Acad Science 93:133262-13366. Pusch M. 1996. Knocking on channels
door: the permeating chloride ion acts as the gating charge in ClC-0. J
Gen Physiol 108:233-236. Pusch M, Steinmeyer K, Koch MC, Jentsch
TJ. 1995. Mutations in dominant human myotonia congenita
drastically alter the
voltage-dependence of the ClC-1 chloride channel. Neuron
15:1455-1463. Jentsch TJ,
Günther W, Pusch M, Schwappach B.
1995. Properties of
voltage-gated chloride channels of the ClC gene family. J
Physiol (Lond) 482:19S-25S. Pusch M, Steinmeyer K, Jentsch TJ.
1994. Low single
channel conductance of the major skeletal muscle chloride channel,
ClC-1. Biophys J 66:149-152.
Jentsch TJ, Pusch M, Rehfeldt A, Steinmeyer K.
1993. The ClC-family of
voltage-gated chloride channels: structure and function. In Molecular
basis of
ion channels and receptors involved in nerve excitation, synaptic
transmission
and muscle contraction, Vol. 707 of the Ann.
N.Y. Acad. Science, p. 285-293. Gründer S, Thiemann
A, Pusch M,
Jentsch TJ. 1992. Regions involved in the opening of ClC-2 chloride
channel by
voltage and cell volume. Nature
360:759-762.
Zifarelli
G, Pusch M. 2010. Relaxing messages from the sarcolemma. J Gen Physiol
136:593-596
Gradogna
A, Pusch M. 2010. Molecular pharmacology of kidney and inner ear
CLC-K chloride channels. Frontiers
in Pharmacology 1:130
Zifarelli
G, Pusch M. 2010. CLC transport proteins in plants. FEBS Lett.
584:2122-2127
Zifarelli
G, Pusch M. 2009. Intracellular regulation of human ClC-5 by
adenine nucleotides.
EMBO Rep.
10:1111-1116
Zifarelli
G, Pusch M. 2009. The role of protons
in fast and slow gating of the Torpedo chloride channel ClC-0. Eur Biophys J
2009 Jan 9.
Vanmolkot
KR, Babini E, de Vries B, Stam AH,
Freilinger T, Terwindt GM, Norris L, Haan J, Frants RR, Ramadan NM,
Ferrari MD, Pusch M, van den Maagdenberg AM, Dichgans M.
2007. The
novel p.L1649Q mutation in the SCN1A epilepsy gene is associated with
familial hemiplegic migraine: genetic and functional studies. Hum
Mutat. 28:522.
Macias MJ, Teijido O, Zifarelli G, Martin P, Ramirez-Espain X, Zorzano A, Palacin M, Pusch M, Estevez R. 2007.
Myotonia-related mutations in the distal C-terminus of ClC-1 and ClC-0 chloride channels
affect the structure of a poly-proline helix. Biochem J 403:79-87.
Pusch M. 2007. Chloride transport across biological membranes, vol 38. Elsevier, Amsterdam, pp 83-108.
Pusch M, Liantonio A, De Luca A, Conte Camerino D.
2007. Pharmacology of CLC chloride channels and transporters. In: Pusch M (ed) Chloride transport across biological membranes, vol 38.
Elsevier, Amsterdam, pp 83-108.
Traverso S, Zifarelli G, Aiello R, Pusch M. 2006. Proton sensing of
CLC-0
mutant E166D. J Gen
Physiol
127: 51-65.
Pusch
M. 2006. Chloride transporting CLC proteins. In: Biological
Membrane Ion Channels: Dynamics, Structure, and Applications (eds. S.
H. Chung, O. S. Andersen and V. Krishnamurthy). Springer, New York,
Chapter 8, Pp. 301-333.
Pusch
M. 2004. Structural insights into chloride and proton
mediated
gating
of CLC chloride channels. Biochemistry (USA)
43:1135-1144.
pdf.
Pusch M. 1990. Divalent cations as
probes for structure-function relationships of cloned voltage-dependent
sodium
channels. Eur Biophys J 18:327-333.
Pusch M, Conti F, Stühmer W. 1989.
Intracellular magnesium blocks sodium outward currents in a voltage-
and
dose-dependent manner. Biophys J
55:1267-1271.
Pusch M, Neher E. 1988. Rates of
diffusional exchange between small cells and a measuring patch pipette.
Pflügers Arch 411:204-211. pdf.